Scientists have mapped the way the group is carrying testosterone, and their surprising results may explain low testosterone levels seen in men with diabetes or some patients. T of cures.
Postgraduate Mateusz Czub and undergraduate undergraduate chemist Barat Venkataramany will investigate the test site of testosterone and discuss the medical effects of their search by Wladek Minor, PhD.
The discovery allows scientists to find out just how testosterone, the male sex hormone, connects to proteins called albumin serum that can be passed through the body.
The results suggest that many drugs link to a serum album in the same way as testosterone, which may explain why the drugs are affecting the behavior of ordinary testosterone. In addition, the researchers say that multiple factors can explain why low testosterone is common in men with type 2 diabetes.
This represents a key decision from one of major projects associated with albumin studied in our laboratory. We do analyzes of serum and human albums, but we are also interested in petrol, rats, mouse and rabbits records. These projects have been active for over ten years in the laboratory. But we cannot stop our research here. We must confront the next big challenge, which ensures that albumin structures are complex with common opioids and abuse. We believe that the determination of these structures could be very important in developing new methods and treatments and our country can fight the opioid crisis. ”
Principal Inspector Wladek Minor, PhD, University of Virginia Medical School
Responses to Low T
The research represents a collaborative operation from a minority language laboratory in the Molecular Psychology and Biological Studies Department of UVA, working with David Hage, PhD, from the Department of Chemistry at the University of Nebraska – Lincoln. . Together they developed the first 3D structure of albumin serum which was attached to a sex horn with binding results, which resulted in unexpected results.
Using a technique called crystallography X-ray, the researchers were able to analyze their components in unbelievable information. But this wasn't easy: At first they had to have a pair inside a crystal set up a trap – a different challenge – and then they could advance a powerful x-ray stream. By following the separation of the x-rays, they could find something very small to even see the most powerful microscopes.
Finding their challenges against the site: There was no Testosterone attached to the predecessor site, which had been pre-empted, but instead of two other sites, associated with georgian acid, a mixture of metabolites and certain drugs. That shows testosterone against a strong competition for transport within the body – important information for doctors not just by prescribing existing treatments but also looking for new medicines. (Albumin serum, for example, is a major cancer drug carrier.) T
It is wonderful that we can use the most up-to-date methods for monitoring brain movements and drugs in the blood on the mollcular level. I hope to combine our results with the results of other UVA researchers so that we can be together to contribute to the development of personal medical treatments. ”
Mateusz P. Czub, Graduate Placement and Managing Writer of Newpaper Paper Download The Discovery
“I am delighted to have contributed to a research project that could be rolled out later to enable translation and real patient treatment in a clinic,” said Ms S. Venkataramany, second author and student. Department of UVA Chemistry. , which was recently admitted to the medical school. The smaller lab, like many UVA laboratories, usually includes undergraduates in its research, which will be of benefit to the students and the research.
https://newsroom.uvahealth.com/2019/03/27/teutaster-slota-m–gaidhlig-eur-and-le sin-men-with-diabetes /