Researchers find out how the junk is attacked by lymphomas in live mice t



In a survey published in April 1 of 1 Journal of Medicical Medicine, researchers from the Institut Pasteur and INSERM explain that chromatic antigen (CAR) cells of the cells of Trom can grow up by targeting and killing cancer cells in particular, finding out new information about how the these defensive cells work and how their effectiveness can be improved in the way that Hodgkin's non-lymphoma and other B-cancers can be improved.

Cells C T are to be genetic defense cells that can be used to attack patient pressure cells. For example, protein T-cells that are called CD19, found on many lymphoma and blood-borne cells, are a FDA remedy that may be used for several B cell cells. including lymphoma and lymphoblastic lymphoma.

But some patients do not respond to anti-CD19 CAR cells, while others, having made initial progress, experience re-breathing and developing shops that are limited by medicine and are not cured. is now CD19. Philippe Bousso and his colleagues at the Institut Pasteur believe that the best way to improve medicine is to learn more about the role of cells T T. For example, it was not yet clear whether Ceallan CAR T was operating. killing the cancer cells or themselves or removing other cells of defense to attack the fur.

For the survey, action researchers discovered CAR-CD19 cells put in mummy cell lymphoma cells. By using a microscopic method called two-bayonic two-pronged images, Bousso and co-workers of individual cells can see a clay killing lymphoma cells in the animal bone. Some cells seemed to be more active than others, but in most cases, lymphoma cells died within minutes of connecting directly with a T T. cell. This was proposed. cells CAR T were marking their goals directly.

"Computer based changes based on our experimental data help the belief that TT cells perform directly as they perform and advance other cells to eradicate the majority larger of the cell lymphoma B in the bone marrow, "said Bousso.

The inputs also revealed that small differences in inner cellular inflection of CAR cell bone marrow can have a significant impact on outcomes. Part of the reason why CAR cells may not breathe in the bone bone if they meet lymphoma cells, or healthy cells that declare CD19, which surrounds the blood. . Bousso and his colleagues discovered that CAR T cells can join these rotating cells and be trapped in the lungs, preventing them from reaching the bone marrow. Reducing these situations – for example, by reducing a temporary amount of B cells – improves the CAR cell cells in the bone marrow and kill dead cells, surviving mice with cell lymphoma t B.

"So, if you can put both fur and normal B cells, that brings clinical benefit by developing decorations and continuity of T T cells," said Bousso.

But anyway, the researchers found that repeating badgers and expressing bruises that find CD19 is found in the bone marrow, instead of other members who may affect the cell lymphoma B, such as bones. the lymph places. This seems to be because the cells T are so active in the other members, minimizing the reasons for loss of bucket cells in the CD19 CD.

"Overall, our results reflect the huge diversity in the behavior of the CAR cell in certain irregular sites that affect engraving, activity against bullying, and reoccurrence. T – a mercury punishment, "said Bousso. "Understanding these differences is an important step forward in the development of strategies to optimize the cells for T T cells."

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Cazaux et al. 2019. J. Exp. Med. http: // jem.ribbon.org /cgi /doi10.1084 /jem.20182375? PR

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