Perhaps the finer cleft is not the most obvious place for looking for depressing sources. But that was the measurement of the British chemist George Porter Phillips in the early 20th century.
When he was walking through the wards at Bethlem Royal Hospital in London, Phillips noticed that his patients with melancholia often suffered from depression, along with other signs of " t breaking hard metabolic processes "- including embossing nails, infertile hair and yellow multi-yellow. t
At first we might be of the opinion that these physical problems were caused by depression, but what if the back was true? Phillips then thought whether it would be possible to reduce depression by remedying the bowel.
To test this hypothesis, he presented patients with a low calorie diet, with no meat other than fish. It also offered a fertile milk drink called kefir in which the lactobacillus bacteria, a "friendly" microbe, were already known to dig.
Amazingly, it worked. Of the 18 patients tested by Phillips, 11 were fully treated. Two others improved big.
The evidence we needed was that our different bacteria can have a huge effect on our mental well-being.
Energetic plant populations are examined
A BBC series analyzed the number of applications about the power of our religious plants to cause damage or damage. But the link between these microorganisms and our mental health may be the most difficult thing to keep track of. How might these microscopic creatures that eat some of our breath affect our brains?
Some of these findings were evaluated. But more than a hundred years after Phillips's original test, the gut-brain relationship is very strong.
“The impact of miracles on our mental health is no longer discussed,” says Jane Allyson Foster, who has a laboratory at McMaster University in Canada, which manages research in this area that we can cure the brain through our belly. “There is a power for healing new medicines and fine medicine.” t
Foster points out that unhealthy innocence is just one of the causes of mental illness. In other words, only a few patients respond well to new "psychobiotic" treatments. But for those who suffer an imbalance in their bowel bacteria, new relief can be given to the new treatments.
Despite early studies, including the Phillips survey, the idea that the legs would have an impact on mental health fell throughout much of the 20th century and there is no robust evidence to suggest this secret association except that. over the last forty years.
One of the most recent tests was carried out by scientists at Kyushu University in Japan in 2004.
They showed that mice were "without microorganisms" – formed in infertile conditions so that their bodies didn't contain microbes – showing more fluctuations in the corticosterone and ACTH hormones, both. stress levels. This recommended that the healthy mouse locks affect their hormonal profile.
The researchers then group a group of bacteria free from insects called lactobacillus bacteria – which Phillips also used as “plastic” bacteria. While these mice were still more responsive than mice not married yesterday, their weight responses were less as obvious as mice without any food in their veins.
There are even some signs that emotional behaviors can be spread through the sex – from person to mouse – due to microbes in the intestine.
In a separate survey, Chinese researchers from Chongqing collected a sample of a pesticides using a Palliative Disorder and sent it to a free bucket mouse.
Later, they found that these mice were quicker up in a "energetic" swimming exercise – behaviors that are often considered similar to infection and despair, routine symptoms of depression. And when the rats were put into a box, they spent time researching the central areas and got closer to the edge, where they felt safer.
“It's amazing that the animals that weren't found are unattractive; Have you been inspired by the Upstate New York Medical University, which was a co-author of the article. "If you change the flowers you will change their behavior."
We are able to draw only some conclusions from these animal surveys, of course, but they are supported by epidemic studies which examine large numbers of human partners (most recent has been published). T on 4 February 2019). These studies have consistently shown that differences in the gutting flowers occur at the same time as a range of mental illnesses, including depression and anxiety.
It does not seem that there is any species responsible for these impacts; it would be much more important than the general share of the different microbes. So the diverse debris of low and anxious people points to less diversity of the mental health problems.
It is little wonder that one of the recent jobs at Licith has revealed schizophrenia associated with poor coal flowers. When a sample of patients who were suffering from the disorder were entered in a freephone mouse, the researcher was able to confirm the current changes in brain activity that were t signal the riot.
These impacts can be many forms.
Some species of carrion will protect the ball's wall, help to prevent the build-up of pollutants that prevent the stuff entering the blood's blood. Without this barrier, you may suffer from a "gut porous", a moving Siondram, dispersing of flame cytokines, proteins that increase blood flow around disease sites. T and managing the organisation's defense response.
While this response is vital to attack a disease, these cytokines can lead to feelings and wind. That is why we are often tired when we are ill – and in the short term, this answer helps us to save the energy our body needs for getting the disease. But in the long term it can cause depression.
Microbes will also have an impact on how we take out and reflect on important prepositions of neurotransmitters, such as serotonin and dopamine. Our multi-leaf flowers have a series of direct communication with the brain through the vagus (or pneumogastric) nerve, which has receptors close to the narrow lines which allow us to control our consumption. So the microbes in the mouth can change chemical messaging that changes the response of the vagus nerve – and so its brain activity.
“Particularly in the bay, there are many opportunities for bacteria to communicate with hospitality systems, including the nervous system," said Foster. "It is a vibrant, interactive and rich place t there. "
But it is not the one-way street. So, the activity of the brain can also affect the formation of the holy plants. Pressure alone can increase swelling, for example, in gut microbes. The result would be a rough circle.
Foster says that research in this area is accelerating rapidly, led by scientists connected with universities and companies.
In the end, the researchers hope that the way they examine their way of life can lead to a new problem for diseases such as depression.
Existing antidepressants work by changing chemical balance as serotonin in the brain, but they are not effective for all patients: only two out of ten people suffer from serious illnesses. development features as well as the impact of plaque. And, although many patients are helping, speech therapists, such as psychological therapy, are just as changeable. As a result, few patients are treated or struggled to obtain appropriate treatment.
There were some attempts – such as the Phillips Phillips survey of 1910 – which fed patients with drowned drinks, such as a kefir, which could be included in the bowels of protein and proteins that they are known to be useful for. Drugs, or soluble roots, called prebiotics, helped. revise our religious plants. Unfortunately, many of these inspections are likely to be small, with few participants, and their results were conclusive: in some inspections, marking interventions were successful; in other studies, they have been better than plaster treatment.
One explanation, Foster, said inspections did not fail the focus on patients who would be substantially benefiting from this type of treatment. After all, there are many reasons for depression, and while gut flu problems may be the root cause of depression or anxiety in some people, in some cases, people can find symptoms of pregnancy. elsewhere, the movement may be quite different. For them, it is unlikely that a probiotic drink will make a big difference to their marks.
To make matters worse, all of us have the essence of being unique – so any treatment that affects the narrow plants must take account of these differences. Generally, if we compare within a column of two people, the cost charge is only 10%.
For this reason, she believes that we need to find more ways of tackling the patient's treatment. “That's how the ferry helps us gutter in medicines.” Hope, Foster says, “mapping“ biotypes ”or groups of individuals sharing particular biology. may prove their markings. " In that sense, it was worth checking that a patient had a severe or low swelling before deciding on the treatment most appropriate to him.
Liquidation is still cautiously confident that future research will identify therapies aimed at the brain. He comments that many drugs have been badly affected by the development of new medical treatments – but such a procedure could avoid such problems. "You're not worrying the brain," he says, "so I think you won't have any side effect as difficult."
The diet of the Mediterranean
Although we still need to improve our understanding of the relationship between our gut and our brains, what we know today is growing evidence of a healthy, balanced diet being an important deterrent to reduce the risk of development such as depression. .
Many of these studies have examined the "Mediterranean diet" – a complete term for reporting a diet full of vegetables, fruit, nuts, seafood, unsaturated fat and vegetable oil, and t reduced sugar and red meat and mutton.
A study in Spain found that the followers of the traditional Mediterranean diet were almost as likely to recognize that they had overlooked four years of depression.
“Data on the importance of nutrition for mental health and brain is now widespread and stable,” said Felice Jacka, nutrition psychologist at Deakin University in Australia and the author of the Brain Changer: Mental Health Diet. good mental health, free translation.
An investigation has shown that the Mediterranean diet has increased the diversity of narrow woolen bacteria and has changed other biological changes, such as a continuous cycle, which are also manifested by depression.
Over a hundred years after Phillips recovered, there is still a downward trend, but for some people a healthy healthy diet could have a negative effect on their health.
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