Data sharing shows five new hazard genes for Alzheimer's disease



Press release

Thursday, February 28, 2019

A NIH-funded project incorporates the largest sample to date for Alzheimer's gene society.

Analysis of genetic data from over 94,000 people has shown five new generation genes for Alzheimer's disease, and reinforced another 20. An international team of researchers also recites for the first time that tenants in genes that are special for dads, a precious protein of Alzheimer's disease, may have an earlier role in developing the disease than originally expected. These new products help to & # 39; Developing evidence that genes related to specific biological processes, such as cell trade, lipid transport, flow and response response, "genetic centers" are an important part of the disease process. The study, funded by the National Historic Institute (NIA) and other parts of the National Health Institutions, and its results from 2013. Will be published online on 28 February 2019 in the magazine Natural Genetics South Westerly

"This ongoing collaborative research that supports Alzheimer's and allows us to digest deeper in the complexity of this accident disease, "said Richard J. Hodes, MD, director of the NIA. "The size of this study provides clarity as well as the genera to prioritize as we continue to understand and improve the target of Alzheimer's and its prevent it. "

The researchers, members of the International Genomic Alzheimer's Project (IGAP), analyzed rare and common genera in 94,437 people with Alzheimer's disease, the most common method of dementia in older adults. IGAP is made up of four United States and European joint ventures that have been working together from 2011 on genome-wide related surveys (GWAS) thousands of DNA samples and a shared database. GWAS aims to find differences in the genome that is associated with Alzheimer's. An understanding of genetic changes can be seen; help researchers to explain the molecular devices that are in place; affecting illness begins and progresses.

As well as confirming its & # 39; known societies of 20 genera with Alzheimer's risk and identifying another five genera related to the Alzheimer's, these genera have been investigated to find out what cellular routes may be. involved in disease process. The route inspection included the protection system, lipid metabolism and pre-amyloid protein metabolism (APP). It has been confirmed that the effects of the APP gene are linked directly to Alzheimer's initially. The current study, carried out at Alzheimer's subjects, ending, suggest that there are changes that are; influencing the APP and the alzheimer's beta amyloid-related protein-related process that affects the beginning and Alzheimer'sSouth Westerly In addition, for the first time, the inspection was carried out; means genetic connection with connection protocols. Taken together, data suggests that remedies that could be developed by learning subjects with early infectious diseases may also be applied to the Alzheimer's form at the end of the year.

The research was led by an international team of experts, including Brian Kunkle, Ph.D. and Margaret Pericak-Vance, Ph.D., from the John P. Hussman Institute for Human Genomics Miller Medical School at Miami University, and Benjamin Grenier-Boley, Ph.D. and Jean-Charles Lambert, Ph.D., from INSERM, Lille, France.

Once the five genera that are involved in Alzheimer's and IQCK, ACE, ADAM10, ADAMTS1 and WWOX- are understood and monitored in conjunction with the 20 recognized species, researchers are in a better position to identify where the genetic centers of Alzheimer's collection are. As a result of these results, researchers can look deeper into these genetic centers to identify drug-related diseases and targets.

A key to these permissions is the size sample, the largest to date for this Alzheimer's type of inspection. A large sample is especially important to find rare genes that may be involved in disease.

"There are more and more samples in the GWAS data sets similar to adding more and more pixel to a picture – it helps researchers to see details that they would not do out and help them decide on where to get further learning, "explained Marilyn Miller, Ph.D., director of the Genetics of Alzheimer's Disease program in the NIA Geology Department. "If the genera appears in one out of ten thousand people, you need to find a number of samples that contain these genera so that the results are statistically important."

Miller emphasized the collaborative facilities that made these footprints possible. In addition to IGAP, the study came from the open data sharing and coordination of Alzheimer's Disease Research Centers (funded by various awards), National Alzheimer's Co-ordination Center, NIA Genetics on a Data Story Site Alzheimer's Disease, the Alzheimer's Disease National Cancer Fund, Alzheimer's Disease Genetics, CHARGE Partnership, and Alzheimer's Disease Family Test at the end of time.

The research was funded by many NIH donations, including AG032984, AG036528, AG21886, AG041689, AG016976, AG049505 and AG056270 from NIA. Other NIH institutes involved in National Heart, Lung and Blood Institute, National Human Genome Research Institute, National Institute of Art and Invasive Diseases, National Institute for Child Health and Human Development, National Institute of Illness, Sugar and Disease and Bone Disease, and a National Institute of Neurological Disorders and Stroke.

This press release gives a description of a fundamental search of research. Basic research enhances our understanding of human behavioral and biology, which is fundamental to improving new and better ways of preventing, protecting and diagnosing infections. Science is an ineffective and gradual process – every investigation generates past searches, often in unexpected ways. Most clinical developments would not be able to experience basic basic research.

About the National Historic Institute (NIA): The NIA conducts a federal government's attempt to & # 39; Supporting and supporting searching for & # 39; getting older and the health and wellbeing of older people. The NIA provides information about an interesting change of age and neurodegenerative disease, especially at the Alzheimer's Disease Education and Adaptation (ADEAR) Center at www.nia.nih.gov/Alzheimers. Go to www.nia.nih.gov For more and more general health, older age. To sign up for email notifications about new products or publications, visit the website.

About the National Health Institutions (NIH):
NIH is a country's medical research agency, comprising 27 Institutions and Centers and is part of the United States Health and Human Services Department. NIH is the leading federal body that guides and guides; supports basic medical, clinical and translation research, and examines the causes, cures and treatments for common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

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Origins

Connect BW et al. Meta-analysis has a genetic connection with Alzheimer's disease that has been diagnosed to loci a new risk and its disease; affecting Abeta, Tau, immunity and lipid process. Natural GeneticsPost-2019 February 28 nd: 10.1038 / s41588-019-0358-2

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