Early and long-term outcomes of bevacizumab plus chemotherapy against chemot



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Jinli Wei, * Yulin Luo, * Deyuan Fu

Thyroid Division and Meaning Medicine, People's Hospital Northern Jiangsu, Yangzhou 225001, Jiangsu, Chinese Public Republic

* These authors added this work fairly

Reason: To better clarify the effectiveness of neoadjuvant bevacizumab plus chemotherapy (BEV + CT) vs. chemotherapy (CT) only when HER2-negatic breast cancer is not dissatisfied.
Methods: PubMed, Embase, Web of Science and Stòr Cochrane have been searched for Stòrlann for relevant articles published from 1 January 2000 to 31 July 2018. Draft software 5.3 of the Review Manager was used to achieve this met-analysis .
Results: Six controlled tests decided outside the electoral criteria, which issued 4,354 patients with early results and 3,777 patients with late results. Total pathology response rates (pCR) and 5-year voluntary survival rates (DFS) were higher for their non-advanced BEV + CT (OR = 1.37 [1.19, 1.58]; P<0.001 and HR = 0.84 [0.72, 0.98]; P= 0.020, respectively), but the total 5-year (OS) level showed that there was no significant difference (HR = 0.79 [0.55, 1.11]; P= 0.180). Sub-group analysis showed that pCR levels were significantly higher in both breastfeeding patients (receptor hormone receptor (HR) – advanced (OR = 1.30 [1.01, 1.66]; P= 0.040) and those with AD negative breast cancer (OR = 1.52 [1.25, 1.83]; P<0.001) in a BEV + CT group.
Decision: Compared to CT alone, BEV + CT non-advanced significantly improved the 5-year DFS level of HER2 negative chronic cancer patients, but did not show a benefit for a 5-year OS level.

Keywords: bevacizumab, non-advanced chemotherapy, chronic cancer, HER2-negative test, controlled by banned

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