Research in the last few years has been linked to the physical or social environment of a person. The weight of their behavior is down to & # 39; body and configure the security system, and # 39; leaving someone more vulnerable to illness and other situations. Different reasons, from family adverse effects, can cause air pollution, diabetes and heart disease.
But scientists do not fully understand how the relationship between weight and health is and, play at cell level. A new study led by the University of Washington examines one major issue that is in the process of being investigated. emphasizing the stagmatization of social quality – and how cells respond to cells that will be released in response to that stress. They found that social status was proofing how macaques responded to the main hormone stress, glucocorticoid.
"The aim is to understand the ways in which social or environmental experiences" can be; getting under the skin, "so talk, affect health and survival," said the author's principal author, Noah Snyder-Mackler, the top scientific psychologist of the psychology.
The inspection is published on December 11th in National Academy of Sciences AffairsSouth Westerly
For this research, Snyder-Mackler and the team turned into a non-human social priority: the raffle macaque. Varied scientists currently have social groups of almost four dozen macaques, behaviors inspected among the new groups, and investigating blood samples to influence the cellular effects of the order new social. The team measurements have a significant impact on the immune defensive system, which is a defensive cell that protects other systems; body, like muscles.
Macaques was a suitable subject for this research, Snyder-Mackler explained, because they are very close to people but without having a lack of cultural or social issues, such as the use of materials or access to medical care, which can co-fit research on human health.
The new study expands Snyder-Mackler's research from the post-executive work at the Duke University, which examined in 2016 that social status had a social impact on defensive systems. The current survey changed the groups of mergers to see how cells responded to what would happen in a short-term weight setting.
In other people and priorities, social status is linked to health and quality of life. Lower social status can mean less social and community support, and fewer stamps against stamps or serious problems. In animals, that is the same as fewer neighbors and greater distress from peers, and in people, lower status is often linked to income, income and unemployment struggle relationship sustainability.
By organizing the macaques in nine new groups effectively created a new social status, write the authors, with the order in which each monkey was also introduced and # 39 ; confirm the status. A & # 39; The first one in the largest group was the largest; and its highest level, and most often the most involved were in the company; maintain the lowest status.
After the establishment of each group's quality and that the team could monitor macaques behavior, researchers gave samples of blood and treated with synthetic glucocorticoid – which produced hormone stress stress, macaques. In two masks and humans, glucocorticoid hormones are put in place to move resources at times when they are more stressed; The ways in which cells respond to an increase in weight hormones are indicate whether the body can respond appropriately to the weight, or whether the strike route is routinely activated, which carries down its & # 39; body and makes it more susceptible to illness.
By using samples of blood treated by synthetics to get to & # 39; Replicating what happens within the macaques when there is a limited pressure, researchers may be able to show how the glucocorticoid hormone may affect the occurrence of Celtic behavior in different macaques – to especially if macaques responded creatively to the hormone stress, or were spent with it and they did not respond appropriately now. In this test, cells of the highest quality macaques were not as capable of those at the highest animals to respond positively to the glucocorticoid. One explanation for this lack of response was found within the genital information of immune cells. By chromatin access measurement – how the DNA is packed in the cell – they found that women at a low level were unable to get rid of their cells; signal from the glucocorticoids.
In people, there are helpful or attractive situations such as job loss, and # 39; caring for a sick child in a bad condition or a love that a person's death has been attached to a glucocorticoid resistant – a physical tax, at a cellular level, has an emphasis on human body. Snyder-Mackler's work recommends any possible equipment, which is a change of chromatin access, which may be affected by glucocorticoid in low-caliber people.
"With shared biotechnology and the history of progress between minches and humans, these conclusions help us to better understand how social status can affect people, "said Snyder-Mackler.
Further research is required, he also added, identifying the size of the effects, as change change in social status, and what buffers that can protect people from these effects. Not every individual responds in the same way as the same stress; some are more sustainable – or tends – to the same weight.
"We know that beginning to life can be a social adverse effect on adult status. The questions are, when these events need to happen, how bad are they doing? ; they need to be, are they recycled or even banned? "Snyder-Mackler said.