Some promising news for children with beetles



/ Each half-membrane effluent produces around 150 mg of nuts.

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There are peanut alangies of food allergies. It's a bad impact to & # 39; Improving bad bad revival in a bad disaster to even a little bit of nuts. For children with these paraffins, the medicine may be the remedy as long as it comes in even more old pain. The results of a clinical trial, which were published today in New England Journal of Medicine, show good results for a cautious responsive program. The cure does not cure the affliction, and it's a? come with big dangers, but it can help children to live their lives without fear of doing; Bring food on everything they eat.

The principle behind which to attack, or aileagylene cure (AIT) is to be a & # 39; adds to the corpse in small and gradual depression; Increasing dose, teaching it to work less when recognizing something that he considers an invasion. In 2015, the Journal of Allergy and Clinical Immunology published a description of its & # 39; international consensus is being handled, saying that although the unconnected approach to wildlife, there was insufficient understanding of its use in handling food cheeses.

AIT has been researching for piping guides, but has not given enough evidence to be an agreed cure. That's why it's a big news in this Stage 3 test release: that's the ultimate stage of drug checks that can be done before the company can apply for the drug being licensed by organizations management as the FDA. However, that does not mean that science is done and everyone can go home – there are enough questions to answer, and more than one test is needed before agreeing .

Picnic challenge

This test included about 66 sites in 10 countries, and recorded 551 patients with beetles. Most of these patients were 496 of them – aged 4 to 17, who are part of it. All of these partners had taken part in the food screening challenge that they saw receiving two oats or one-day bone bone protein, and then the other food on the second day. The idea behind this is to make sure that & # 39; partner whether they were eating or not eating, and the person who gave them the food did not know what they were eating, either. There were only people who affected their silent hidden protein. the lawsuit.

Then, the participants were randomly randomized – one season in the placebo group, and # 39; Avoiding powder equivalent to the medicine but without any protein, and three quarters set to get the cure. This cure began just 0.5 mg of acne acid protein in the first dose, and over 24 weeks, gradually increased to 300 mg-around the same as a single piece. Then the level of maintenance came up: 300 mg per day for another 24 weeks.

When the cure was past, the results were very strong. In another food challenge, the researchers confirmed how tough the participants were suffering from. This started with a low dose of nuts protein and, if that partner was allowed, he put up the dose on the next round. Only eight per cent of children in the placebo group were doing around 300 mg, compared to 77 per cent of those in the hospital. medical group.

On the next 600 mg, a fifth percentage of children in the placebo e group made, and 67% of those in the place medical group. And 2.4 per cent in the placebo group could tolerate 1,000 mg of poisonous protein, compared to a half; medical group. Among the 55 adults confirmed, the differences in reactions to the important food challenge in statistics were not.

Standing with the Epipen

By showing a large group of children to his / her. food, they are very disturbing, to get rid of it, not at all at risk. There was a high level of almost 12 per cent in the active group due to bad effects, and almost everyone Getting the cure that affects the treatment time, and two thirds of them are median or bad. This may not be entirely susceptible to the cure itself, but it is higher than the level of the placebo group, fewer than half of them had a medium or bad event during the test.

During the final food challenge, five percent of children in the medical group had a poor response, with a 25 per cent answer. This was much lower than the level in which; placebo-11 per cent group and 59 per cent, individually – but it shows that the cure and the test have been of significant risks. "It's not something here to start at home," wrote the epidemiologist Michael Perkin in.

It is a major weakness of the test in the maintenance period for six months. Testing of long-term maintenance medicine is underway, but at this stage, there is no evidence that shows how long the maintenance of the tendency is likely to be effective, or even safe. If you have long-term maintenance, do not work; Continuous control of patients, and maybe for his / her; rest of their life, and Perkin's writing: "The immunotherapy problem is that the rash tolerance is temporarily stimulated and lost if it is consumed regularly. "

Despite these warnings, there is no doubt that this is an interesting story and welcomes children with beekeepers. "Most parents would often see spending a little nuts with their child as a small price to pay to keep the dangerous risk of system anaphylaxis nearby," said Perkin.

New England Journal of Medicine, 2018. DOI: ().


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