MADRID, 5 December (MAIN EUROPA) –
Researchers in Brazil have identified a The relationship between oral cancer continuity and abundance of certain protons present in tight meat and saliva, who may report predict the progress of illness.
In particular, the results, published in & # 39; Natural Communications & # 39;, identify a strategy to overcome clinical tests and images constraints, and can help guide the choice of good cure for all patients.
In order to achieve this work, researchers carried out a statistical analysis of woven from various types of illnesses that used 120 symbols with microdisected, and confirmed the prefix prefix 800 medical samples with immunohistochemistry and 120 samples with guided proteomics.
"The data has been raised to strong results that are very promising to explain how difficult the disease is, and to suggest symptoms that may have the disease In the first phase of the inspection and demonstration of these second-level indicators, which improve the reliability of the results and show that these indicators are effective in disseminating the results patients with the limit of cervical lymph, "said experts.
Mouth cancers, also known as oral cell carcinoma (OSCC), are the most common type of malignant immersion in head and neck. Relevance and dying is high, with it 300,000 new cases is determined annually throughout the world and 145,000 deaths. Although it is very easy to find, it is usually proven in advanced stages.
TWO STUDY FACILITIES
In particular, the work was done two stages. In the first one, researchers used microdissection laser and proteomics to map the protons in arable mussel to & # 39; mouth and in combination with the clinical characteristics of patients. I allowed this analysis to be marked Several prints, such as CSTB, NDRG1, LTA4H, PGK1, COL6A1, ITGAV and MB, with different levels of presence depending on the space of the tumor and links to key clinical outcomes.
In the second phase, after the identification and measurement of protons in the item More than 120 samples of sickness weaving, researchers put in place two profit-proofing strategies. One single measurement strategy of prototypes selected in independent medical samples, and # 39; using immunohistochemistry with antibodies, while the other monitored the same targets that were given in a patient saliva.
Saliva was selected because this cancer is found in mouth, where the neoplastic cells can protect proteins. "Saliva is a promising source of signs, as well as being a sound with a non-invasive collection, we checked out the protons in a saliva of 40 patients, and we checked the tea technicians to achieve the highest level of confidence for the results of this level of study, "researchers explained.
After analyzing the saliva chips, they used biological biology and learning methods to reach the prognostic names, and Determine which the first-phase protocols or peptides that may be between patients with and without cervical lymph nodes.
From this result, the specialists can identify three distinctive features (LTA4H, COL6A1 and CSTB), which can be used as a signature for a & # 39; classification patients with and without median in the lymph cervical nests, which offers the ability to & # 39; help doctors find out about clinical examinations, as well as managing personal handling strategies.
Now, Brazilian scientists are working on a new study designed to use translation techniques to build accessible biosters who can find prognostic signatures in a patient's saliva.
"We want to develop a simpler and cheaper way that health professionals can easily use to improve the disease based on tests that can be done in a doctor's dentist or office, or in clinical surgeons. We intend to develop a biopsy focusing on the use of this signature so that it can be accepted for clinical use and help with medicinal results, "they have settled.