Creating a new risk for osteoporosis promises a new theory


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Scientists announced a new risk of osteoporosis using the latest breath analysis tools t

Scientists have identified new risk gestures for osteoporosis, the weak weakening condition that causes millions of people. You can know about the genetic genes of re-opening the door to more efficient treatments.

“Recognizing that the main cause of disease is often helping with steering us for the correct, targeted,” said director of Struan F.A. Grant, PhD, director of the group. Center for Spatial Genomics and Action (CSFG) at Philadelphia Children's Hospital (CHOP). “We have identified two new species that affect cells that make bones that are appropriate for incision and osteoporosis. In addition, the research methods we have used could be used more widely with other diseases with a genetic component. "

The survey identified two new species, ING3 and EPDR1, to have a profound effect on human ostentoms, a type of bone cells

Grant and his colleagues publish their research Nature Communications. He co-directed research with Andrew D. Wells, PhD, immunology researcher at CHOP and another director of the CSFG; and Kurt D. Hankenson, DVM, PhD, an expert in bone formation and reorganization at the University of Michigan. Grant and Wells are also members of the faculties of the Perelman Medical School at the University of Pennsylvania.

The inspection team investigated genetic locks, or DNA sections, previously set up for combining bone mineral density in genetic society (WAS) surveys, both in adults and children. “Scientists have been accustomed to time for a disease that the closest gene for some form of disease is not linked to the disease,” said Wells. As the WAR research seeks single-phase changes in DNA that are not normally located in clear areas of the species, much research has turned into a wider context of interactions within the genome – the full of DNA within cells.

Sometimes the changes, known as single-nucleotide polymorphisms, or SNP, found in WAS are found near culpit gene. More often the signal comes from a section that does not contain a DNA code that manages another gene that may be thousands of coins on the DNA chain. “There's no genealogical form of generation,” said Grant. “Because DNA is plugged in chromosomes, parts of the species may become physically informative, allowing important biological interactions that affect genealogy. of the application. That is why we are examining a three-dimensional structure of genes. ” T

In analyzing how chromatin, the threads making chromosomes, are placed into specific shapes, spacing genetics gives a vision of how genes interact physically with the administrative divisions in DNA that begin transcription. The first event of a gene sentence is a transcription of the process in which DNA is copied to RNA.

The survey identified two new species, ING3 and EPDR1, to have a profound effect on human ostentoms. “Although we do not remove other twins in these areas, that is ING3the gene was especially standing out as we discovered it was the genetic sign of this area. the strongest one that's linked to a density of bone at the wrist, the biggest site of infraction in children, ”one of the authors.

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