How does the brain recognize false proteins?


The complexity of a new protein found to provide a healing method

Researchers have identified a protein mark in the brain that names badly-managed proteins, keeps them from destructive interactions with other proteins in the cell, and puts them out to get away. The new footprint listens to the slender name “Horizontal Commonwealth Linear Ubiquitin Chain”, short LUBAC.

From previous studies it is known that Protecting LUBAC protects the protection routes protecting defensive defenses who rule through the medium of the transcription NF-kB to be. For example, LUBAC can be employed to connect to bacteria in the cells, to operate the NF-kB there, and so start a protection response.

"Our survey shows one To date, we did not know that there was a LUBAC system"said Konstanze Winklhofer, a member of the Amazing Messenger, Ruhr, who makes a study of Solvation, or Resolv for a short time."LUBAC seems to recognize animated proteins as threats, carrying them with ubiquitin line chains, providing them with no cell for the nerve cells."Unlike the answer to bacteria, this act of LUBAC is independent of the factor writing NF-kB.

The collection of incorrect proteins is poisoned to cellsbecause it affects a variety of processes. Among other things, they have an interactive surface that connects other proteins that are necessary for the cell and therefore discard them. This worries the work of the nerve cells, they die.

Prevent protein interactions

The science scientists were able to clarify the equipment described above with an example of the hunt hunt, which is followed by Huntington's disease. a & # 39; Including line ubiquitin chains to bring together the hunting. T protecting the extremities from non-cellular interactions make it easier, In Huntington's illness, however, the LUBAC system has a concern as the team was able to demonstrate.

Equipment works for different proteins

The impact of PSBD protection is not restricted to hunting collections. The researchers also found chained ubiquitin chains together a protein which is part of other neurodegenerative diseases, such as a lateral amhaotrophic specialty.

"The tie-ubiquitin chain link is a link." a very special processas only one part of LUBAC – just the case can be resolved, "Winklhofer added Strategies for alternative treatments come to top. "

In future inquiries the team are keen Identify small molecules that may affect linear regeneration and test their impact on neurodegeneration tBut it is still a long way to go before it develops drugs.

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