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Cellular model development researchers are very aware of their ability to & # 39; Exploring complex effects of anti-inflammatory drugs

Jena's international geographers and partners provide a very fragile test system for anti-inflammatory drugs

Drugs such as ibuprofen are not aspirin which typically emphasize lower pain and fever among drugs throughout the world. They are used above all for the recovery of energy recovery. However, despite the inevitable force and their usual use, we still do not; Understand the fundamental methods of those drugs. In addition, when these drugs are taken, there is a negative effect and again, their reasons are not sufficiently clarified too.

The research team is led by medical practitioners Dr Jana Gerstmeier and Professor Oliver Werz of the University of Jena to develop a cell module to get answers to these questions. As the crew scientists recite in the specialty, & # 39;The FASEB Journal&, Have succeeded in & # 39; clarify the complex impact of active companies that are administered when specific signal content is created in long-term protection cells. reasonable answer (DOI: 10.1096 / fj.201802509R). In the future, this will enable the development of new active drugs with fewer impacts. Workers from the Harvard Medical School in Boston and the Karolinska Institute in Stockholm were also involved in the research work.

There is a two-stage blast

"Disbanding – a little talk – in two continuous stages," explains Markus Werner, a medical student at the University of Jena Medical and Medical Chemistry Chair a & # 39; first author of the survey. During the first stage, the cells are immune & # 39; M1 & macrophages active. They produce tuberculosis (prostaglandins and leukotrienes) from unsolicited fat asses, Promoting normal symptoms such as fever and pain. Within a few days, the second phase begins, in which the inflammation is resolved. In this moment, macrophages are M2 & # 39; active, which creates messenger products to & # 39; Solution from the fat asses (called resolvins).

"Normal drugs engage in two levels," said Dr. Jana Gerstmeier. "They will reduce both proinflammatory messenger products and interlocutors to their content resolution." This will reduce its & # 39; First wise revival, but at the same time it also prevents the second phase in which the solutions are in place; a solution. "There is a danger that a stream will not stop and continue, until secondary infections occur." Sufficiently, drugs should thus be reduced but strictly, but it does not restricting the extent to which it is resolved.

The particular feature of the procedure is its sensitivity

The newly-developed cell model enables researchers to investigate the effectiveness of drugs in two slow rates. "For this reason, we use human protective cells (M1 and M2), which we will prepare with the drug to be tested before they submit a reasonable response by & Using reusable bacteria, "a & # 39; explains Jana Gerstmeier. The messenger products released by the cells are inspected.

The specific feature of the modified Jena process is the sensitivity: the effective second-phase blasting materials are effective in installments of around 1,000 times lower than the inflammatory signal of their first stage of swelling . Certain checks are needed to find those materials, and Jena's laboratory is one of the few laboratories in the world to teach this method. By using a large spectrum, it is & # 39; Finding a number of twelve dozen memorandum released and a separate specimen is created for each active device. This allows the results to be drawn to the effect of the # 39; Drug on its total energy process.


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