Meta-analysis of many studies is in the back of the genital Toundte syndrome (TS) – a neurodevelopmental disorder marked by an unusual and continuous motor of a motor – to find that The changes in hundreds of genres, working together, & # 39; contributes to the development of syndrome and includes Tourette as part of a broad overview of tick problems, and # 39; ranging from middle issues, sometimes moving to hard issues; It may be possible to include mental signs.
The report from an international team – led by inspectors at Massachusetts General Hospital (MGH), University of California in Los Angeles (UCLA), University of Florida and Purdue University – also says that individuals are more TS-related changes that have a bad impact on them, and & # 39; Raising the ability to predict whether children with light heat problems TS develops full-bleaching in the future.
"This study confirms that the Tourette genetic foundation is at risk for most patients – that is, many genera are working together to cause disease," said Jeremiah Scharf, MD, PhD, the Center for Psychology & Neurodevelopmental Genetics of the MGH de Neurology and Psychiatry departments and the MGH Center for Genomic Medicine, co-head and corresponding author of the report in American Journal of Psychiatry"This means that most people who do not have TS generates one non-active gene but instead they are possessed Hundreds of small DNA changes from the two parents who come together to make TS. This product has many important effects, both scientifically and for the patient's application and understanding of their symptoms . "
Although he knows that most of the risk for TS is to be possessed, there are very few cases identified in the gene variations associated with the risk identified . Many common genera have been associated with a greater risk of diseases, and suggest that large-scale society surveys (GWAS) might clarify the potentially hazardous genera and who does not contribute to the TS development.
In order to achieve the highest data position, the auditors met from the same GWAS study published by new data from three international genetics partnerships – the American Tourette International Genetics Association, the Gilles de la Tourette GWAS Replication Initiative , and the International International Glossary Survey Tourette – for 4,819 people with TS and nearly 9,500 volunteers who have no impact. Secondary analysis of data based on the analysis of Icelandic based dentist genetics compared to over 700 people with TS to over 450 with other tick problems and more than 6,000 controls.
The result of this analysis identified a variety of genes – none of them were only the same; meets the importance of genome around the world – associated with more risk of TS. Use the general polygon risk score that is based on the identified risk changes to examine each person in the study – both with and without TS, as well as people with difficult check-ups – they confirmed that the symptoms were more However, the TS-related changes were not restricted to those with tick problems.
"All of the changes that contribute to the development of TS are present in an important proportion of the wider population, which does not mean that there is no" Most people with TS virus are "broken", "said Scharf. "The motions and thoughts of people with TS are the only ones we all have, but just a bit larger. As doctors and researchers, we know there is nothing that divides Those with TS from other children and adults, and now we have confirmed that this is truly genetic. "
By developing a polygon risk score for TS, it is possible for the future to be & see if there are children's symptoms that tics develop, get worse in early childhood, missing or not solve length & # 39; s is the child's growth, which is not possible Next Postgraduate exams should register more groups of partner organizations to develop this preliminary ability.
"This study is an example of the great impact of collaborative research to be able to finally understand the purpose of complex diseases," says Peristera Paschou, PhD, a professor associated with the Department of Biological Sciences at Purdue University and one of the co-authors. "As the next step, we are now expanding analysis into a even larger sample of nearly 12,000 patients with TS, again able to thank broad international cooperation. We hope that this will bring a higher power to clarify TS's genres. "
The co-director of Jae Hoon Sul, PhD, of the Jane Institute and Terry Semel for Human Ecology and Human Behavior at UCLA, said, "We need sample sizes for specific genes that cause TS , and there is a continuing collaborative effort across the USA, Canada and Europe to increase numbers to thousands of individuals with TS, which will ensure we have more opportunities to develop more genes related to TS. We can only work with us all that important goal. "
Scharf, a professor of Neurology at Harvard Medical School, says that most of the brain are most likely to influence the threatening changes in the polygonal risk score as part of a visit that is involved in learning, planning and a suitable motor selection or activities, areas previously proposed to supplement TS and other disagreements. "Existing pollutant checks – both brain and non-brain based – have shown that even though only one gene generates a small part in causing disorder, Each generation may be a candidate to understand disease devices and get new medicines. We hope to continue to detect a new TS gene, that we get new medicines that are most effective without having bad effects related to current treatment. "