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CRISPR reveals a secret life of antimicrobial peptides – ScienceDaily



When it comes to the protection system, we usually think about lymphocytes such as B and T cells or macrophages; Continue on ongoing missions that are searching and sent to; Destroy against attack patagas such as bacteria and viruses. But our protection system includes real protection protection; identifiable and unrelated "protected protection".

One of the main protective devices in a family of small peptides, also known as "antimicrobial peptides" or AMPs for short. AMPs are made by the cells of hospitality (for example, humans) and combat attacks of insect organisms by a & break out their cell shades or by eliminating their actions.

Despite how important they are, we do not know much about AMP. Some in vitro surveys have shown that they can kill bacteria and fungi, but scientists have been struggling to study them in living organisms. One of the reasons is that there are too many issues in safeguards, so an individual AMP angle in living livelihood is a very complex proposal.

But now we have the tools. Scientists from Bruno Lemaitre's speech at EPFL's Global Health Institute CRISPR, a generational method, do not delete without less than 14 AMPs from the Drosophila evaluation fish. By deleting single AMP genes, a different variety of genera, or even 14 gene, b & # 39; scientists can remove their compatibility AMPs and look at how the absenteeism affected the snow that baffled with bacteria and fungi roots.

The results, particularly in Drosophila, show that AMPs are working strongly against Gram-negative bacteria (for example E. coli, species of Enterobacter) and special fungi. The AMPs also work either together or by adding to their respective effects. Surely, they found that some AMPs can be extremely special in the protection against a particular disease (for example, AMP dipterics against P. rettgeri). This unpredictable product improves an unidentified level in advance of the immune protection response.

"It's an interesting thing that these results help us to understand how our AMPs can help fight them," said Mark Austin Hanson, first author of the study. "Some people who need to prevent general disease – for example, uropathogenic E. coli – may have a faulty copy of a specific AMP – and so are at risk more It is a good fight against a disease, but learning how to prevent it in the first place is a good cure. That's what AMPs do: they're going to do it. ; preventing disease before entering it. "

But the requests for AMP monitoring are going later, Hanson wants. "Exploring how the AMP explores the flight also helps you to manage economically important insects, whether it protects bees -math not to prevent mosquitoes from discharged disease.

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Materials supplied by Ecole Polytechnique Fédérale de LausanneSouth Westerly Note: Content can be edited for style and length.


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