A new study led by the inspectors of Massachusetts General Hospital (MGH) finds that radiation treatment could cause the movement of nanoparticles by glioblastomas, building on the incidence of optometrists and a protective system. used against deadly brain tumors. The team describes how pre-activity with low-level radiation delivered delivery to the nanoparticles movements of small RNA molluscs and transmission improved by a mouse model of glioblastoma.
“We found that radiotherapy bursts reduce as they grow to the level of surgeons, allowing us to develop a nano-earth target to deliver siRNAs for the survey with protective and protective properties. hearing aids against the brain in the healthiest brain, "said Bakhos Tannous, PhD, Department of Neuro-Oncology in the Neuroscience Department of MGH, the senior author of the published report t ACS Nano. "A short movement of radiation was capable of accommodating the snaoparticle up to five times, affecting target medicine, enforcing the protection at the box site and giving survival."
While up to 60 per cent of the reported EGFR growth trend, molluscs used in targeted treatments against several types of cancer, treatments targeted by EGFR were not successful brain diseases. Immunotherapies that are directed against protective tests such as CTLA-4 and PD-L1 have also had positive results against cancer, but there is still no glioblastoma. Some studies have suggested that there is a link between EGFR activity and increasing the definition of PD-L1, highlighting the potential that the two targets could increase the antitumor impact.
To deliver the siRNAs focused on both EGFR and PD-L1 to brain diseases, snaoparticle researchers developed a hard lipid led by a peptide target targeted by iRGD, which links to a molecule. presence of bristling blood vessels giving the blood vessels a blood vessel and blood and t Factors such as small size and the positive attack of this nanoparticle allow it to be used as a blood detector; and as other hard lipid naoparticles, its low cost, sustainability, biosphere and coldness make it an attractive option, describing Gulsah Erel-Akba, PhD, from the University of Neuro-Oncology and Izmir Katip Celebi Turkey, the first author of the survey.
In order to test the pretreatment of low-dose radiation with the nanoparticle effectiveness of the antibiotic, the researchers compared the results of four strategies of glowing mice.
- Only with radiation treatment or the nanoparticle containing siRNA molecule affected; grown thinking or survival of the mouse.
- The introduction of the iRGD-controlled nanoparticle by conducting siRNAs by EGFR / PD-L1 without rape pre-enforcement has had a moderate effect on growth of shops and survival from 21 to 24 days.
- Radiation and nanoparticle pretreatment also had a moderate effect with arthritis carried without an effective guided peptide on both growth and growth.
- Radiation and nanoparticle pretreatment with iRGD that used to target EGFR / PD-L1 siRNAs that were growing live to 38 days.
Examination of diameter sites detected that joint cure showed decreased PD-L1 and more collection of cells T8 CD8, which indicates a greater protection response to antitumor.
Tannous, a distinguished professor in Neurology at Harvard Medical School, explains that radiation affects the micro-environment of a non-protective glioblastoma in a number of ways, suggesting that action is active. providing and improving antitumor protection. Although parts such as the best dose and the time when radiation pretreatment is not provided are still verified, it says that the same approach can be taken to dealing with other offensive stores with siRNAs aimed at routes. T morphological.