Lack of sleep accelerates Alzheimer's brain damage: study


When they were learning mice and people, researchers found at Washington University Medical School in St. Louis has a lack of sleep to increase tau levels of Alzheimer's disease, and the insomnia is a accelerated spread through the brain of toxic material. Groups of babies, who harm harm to brain damage and a fundamental step on the road to dementia.

To find out if there is a lack of sleep just to stop up tau levels, the researchers have a & # 39; Measuring tons in mice with normal and blocked sleeping, and found that tau levels in the sound around the brain cells were around twice a night, when the animals were more active and vigorous than through Day, when the mice was more frequent.By disturbing her & # 39; rest of the day-to-day mice, the daily tau levels cause duplication.

The same effect was seen in humans. The cerebrospinal energy obtained by researchers eighteen after a normal night of sleep and again after they were awakening all night and show that a night of ; Patient tau levels up 50%.

To produce capacity for stress or behavioral changes to & # 39; explaining changes in tau levels, the mice researchers created currently modified potentially awakening for hours by coping; putting them inappropriate. When the device is removed, the mice return to their & # 39; their normal cycling, signs of stress or desire to sleep more.

Using those mice, find the researchers that they are; stay awake for a long time that means tau levels are rising. Taken together, the conclusions say that tau is routinely distributed at times awakened with normal thinking and a & # 39; do, and then this discharge will be reduced through sleep, & # 39; let tau be abolished. Sleep deprivation will prevent its & # 39; This circle, which allows the tau to accumulate and enlarges the presumption of the protein; begin to collect in a casual connection.

In people with Alzheimer's disease, tau tangles tend to appear in parts of the brain that are important for memory, hippocampus and mental cortex, and then spread to other parts of the brain.

To investigate the effects of sleep on spreading nod spreads, researchers put the hippocampus of mice into small groups and then the animals would wake up a long time of day. Another group of mice was also arrested by tau entanglements, but were able to sleep when they wanted. After four weeks, the seabirds had a larger spread in sleeping mice that were in the wake of what they were doing; rest. In particular, new towels appear in the same areas of the brain that affect people with Alzheimer's.

The researchers also found that a breakthrough was spread more than a synuclein protein, in recognition of Parkinson's disease. People with Parkinson's disease often have a sleeping problem, like people with Alzheimer's.

"Something really sleeping is something we should all try to do," said the author, David Holtzman, professor and head of the University's Neurology Department. "We need time to get back from a day's problem. We still do not know if you need to sleep enough as people & # 39 ; getting older to protect Alzheimer's disease, but can not hurt, and this and other data suggest that they can help with delay and reduce down a disease process if it's started. "

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