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Showing a 3D image to start as pancreatic cans begin



The image showing cancer is & # 39; grow inside the pancreatic mouse relationship. It was found to use a new method for checking 3D medical examples, and # 39; shows that starters can start as endoustics & endocytic towers which penetrates into the passage (shown here) or towers & # 39; exophytic & a; grow out. Credit: Hendrik Massal, Francis Crick Institute

A new approach to the study of 3D medical samples has shown that pancreatic cancer can start and grow in two separate ways, and a mystery resolution of decades of how tumors create.

The new method may be to assist researchers to get more information from being able to; making beard biopsies and there may be better cures for pancreatic cans. The methodology was developed by scientists at the Francis Crick Institute, and their findings will be published NatureThe post was supported by the European Research Council and key funding from Cancer Research UK, Medical Research Council and Wellcome.

The pancreas is the vital organs that sit on the stomach and play play an important part in handling. It is dependent on a network of types that link it to other groups that are exploring, and the most common pancreatic canals are found in the tools. However, so far, it has been possible to see 2D slices of these ductile cancer, which had an unfamiliar combination of unusual shapes.

"To investigate pancreatic cancer sources, we spent six years developing a new way of analyzing cancer biopsies in three dimensions," a & # 39; explains Dr. Hendrik Messal from Francis Crick Institute, co-directed by author; research paper. "This method shows that cancers grow in the relationship walls and enter or out by the size of the duct. This sets out the shape differences mystery we've been seeing in 2D slides for decades. "

Analyzing to & # 39; The development of canals in 3D, the team explained two different types of cancer production that comes from ductal cells: tumors & # 39; endophytic & a; grow into the ducks and towers & exophytic & # 39; who grows out. In order to find out what cancer cells grow in a unique way, they have analyzed 3D detailed images and work with biological experts at a & # 39; Chrick who created excellent computing modules.

"We have compiled the parameters, describing the geometry of individual cells to understand a medical shape," a & # 39; explains biological expert Dr Silvanus Alt, co-directed by author; paper. "Confirmed the model and the experimental results of cancer growth when the duct's diameter was less than about twenty micrometers, about fifty percent of the engineer."

The work was made possible by interdisciplinary collaboration between two research groups at Chrick, led by Dr Axel Behrens and Dr Guillaume Salbreux. The Axel group works on pancreats and pancreatic cancer, as long as Guillaume aims to have a & # 39; Using physics for understanding biological processes.

"I think we started this debate first when we stopped each other in a bitch shed," said Axel. "It's amazing about what we can do with our communications, we now have a patented way to see three-dimensional shapes of canons and have a biological understanding of origins. Now we know that we can develop pancreatic cancer in these two different ways, we can begin to look at at least one of them more likely to be more aggressive or discharged in Different ways. Many years from here, this can lead to better assessment or treatment options. "

The team sent the procedure to other organizations, and found that cancers in the airplanes of the lungs and the liver-based tools are transported in the same way. This shows that the device is not detected by the specific pancreas teams and also; related to other cannons.

"Our data and modules show that the two different ways of tower growth just go to the system's interesting physics," a & # 39; explains Dr Guillaume Salbreux. "Like most clans, ductal pancreatic cancer begins with one empty cell that starts to divide. We got it very quickly, when there is no just a few cells, the tumor has begun to grow in or out according to the diameter. A fundamental process will help us to better understand how cancer and growth in many places throughout the group. "

Professor Andrew Biankin, UK Cancer UK's pancreat cancer expert, says: "This technological technique is able to solve many unresolved issues that are very important in how we can understand and what we & Treating pancreatic cancer. It is essential that we gain a better understanding of how those cancers are carried from the first stages, to help develop cures for disease where there are still live rates has been very low. "

This article was reprinted from materials supplied by Francis Crick Institute. Note: Items may have been edited for length and content. For more information, contact the well mentioned.

Mention: Hendrik A. Messal, et al. Medical diagnosis and imbalance are mechanical tensioning of cancer morphogenesis management. Nature. DOI: https://doi.org/10.1038/s41586-019-0891-2


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