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But another study creates doubts about whether a alcohol has a beneficial effect on the heart



You may have been reading about research that is very good for you to take a few loaves for food. On article videnskab.dk you keep healthy: Drink three glasses of beer each day it says, for example, it should be good for the heart.

But maybe you have also read the other side. In fact, the research is not quite clear. Although many studies suggest that 1-2 units per day reduce the risk of blood blood and strokes, scientists cannot be sure that it is being affected by the drink.

Now, the topic of The Lancet scientific journal was extensively examined. The researchers are not making any positive impact.

– It's a superb examination with an interesting way, but I'm not sure they can refuse a favorable effect, says Janne Tolstrup, who is a professor at the University of South Denmark.

We will return to the "interesting" way a little later in the article. First of all, it is important to find out why it is so difficult to find out whether some alcohol is strong or harmful.

Previous studies have suggested a positive impact

It is not pulled out of the air that some alcohol could have a positive effect.

In previous population surveys, which write amongst other things videnskab.dk has written, the researchers are looking for a U-shape loop. Those who do not drink alcohol are therefore more at risk and those who drink alcohol have a blood problem.

Those with alcohol consumption have a lower risk.

· The problem is that it has not been shown to drink. Those who do not drink may also be more ill for other purposes. Some of them are also thought to be alcoholic drinks, which remain more at risk, according to Tolstrup.

The new research is based on the genetic categorization of the partners.

In East Asia, it is more common to adopt a gene that makes it unpleasant to drink. The sensitivity to be known as “Asian Flush” is due to the flow of the face. (Image: sunabesyou / Shutterstock / NTB scanpix)  t
In East Asia, it is more common to adopt a gene that makes it unpleasant to drink. The sensitivity to be known as “Asian Flush” is due to the flow of the face. (Image: sunabesyou / Shutterstock / NTB scanpix) t
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In East Asia, it is more common to adopt a gene that makes it unpleasant to drink. The sensitivity to be known as “Asian Flush” is due to the flow of the face. (Image: sunabesyou / Shutterstock / NTB scanpix) t

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Genetic differences make the result safer

In the new survey, researchers have seen more than 500,000 people in East Asia over a ten-year period.

People might say that people who have 1-2 units each day have the least risk of blood cover and stroke.

But the researchers also found that around 160,000 people are at the same time who have two gene variations which make them more likely to drink.

– Some of them are fitted with a nature brake. "It doesn't matter," said Tolstrup.

In discovering this group, the researchers were able to ensure that participants were not with the lowest levels of alcohol in other ways.

This method is known as a mendelian amount and will simulate random tests, also called lotteries, which are called gold research status, as the same difference is between the two groups. is causing less.

Avoiding confusion of risk factors

So the researchers sought the participants

The researchers have gathered data on over 512 715 adults aged 35–74 who have been continuing for 10 years.

In 161 498 of the participants had one of two types of gene that reduced the number of drinks they imported.

In East Asia, there is a larger group of people with one of the genealogies ALDH2-rs671 and ADH1Brs1229984:

  • ALDH2-rs671 causes body behavior to break the acetaldehyde drug, as alcohol has changed to physically, a lot slower. According to the survey, this change in gene is significantly reducing the amount of alcohol.
  • ADH1Brs1229984 causes the body to break down acetaldehyde faster, and according to the survey, this change in lowering gene can take alcohol, but not so much.

Using both groups, the researchers could look at how alcohol consumption might arise due to illness or other factors.

By dividing the topics into groups with and without the genetic species, researchers can be more certain that drinking down alcohol is lower as a result of the genes, not disease.

– Genetics is a way of analyzing the health effects of alcohol and finding out if harmful alcohol is protected or injured. Our genetic study helps us to understand the relationship between cause and effect, which says Iona Millwood, the leading researcher at the new research and associate professor at the Population Health Research Unit at University of Oxford in a press release.

Janne Tolstrup agrees in part.

– The differential difference removes the disruption to risk issues. But they say it is a sensible way, and I disagree. They are finding coincidence, but on a safer basis, Tolstrup says.

– But it is a good study, and it is interesting to explore this gene in East Asia, where it is more common.

Research: Four units a day are threatened by 35 per cent

The researchers noted that the 1-2 units per week had the lowest risk of blood and kidney failure in the 500,000 participants.

However, with the two genetic modifications, where the researchers could be better informed of the results, the researchers found that the drinkers were the lowest drinkers.

The study concludes that four units of day alcohol increase the risk of a 35% stroke, and four units to increase risk by another 35%.

How do we find out if alcohol is for the heart?

But Janne Tolstrup is not entirely sure. Although the new research shows the lowest risks to those who did not drink, there are also studies to show other outcomes.

What we need to say is according to Tolstrup, a random test, where the only significant difference between two groups gives one 1-2 units per day over a number of years, and isn't the Another is drinking.

– In fact, some researchers were doing this kind of test, but it was shut down that he was too closely connected with the search director. the alcohol industry. But such studies do have to say something about causal relationships, she says.

description of him:

I.Y. Millwood et al: "Conventional and genetic evidence of alcoholic science and rheumatism: a possible study for 500,000 women and men" in China, The Lancet, 2019. DOI: http: // dx .doi.org / 10.1016 / 0140-6736 (18) 32214–1

© Videnskab.dk. Translated by Lars Nygaard for forskning.no.


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