The physical, social and recreational activity used by older people and patients with Alzheimer's disease can help to maintain mental careers and their careers. delayed memory loss, according to a new study developed at the University of São Paulo (USP) and the Faculty of Santa São Paulo Medical Sciences. Promotions promote morphological and active changes in the brain, which protects the organ from enemies that cause mental impairment.
The search was made through tests with transgenic mice, which were converted into a generation to enhance the sensory plates in the brain. These records are one of the symptoms of Alzheimer's disease. The animals were divided into three groups: the transgenic that was given stimulation, the transgenics that they could not get and the unintentionally controlled animals.
"When they were a little older, about 8 to 10 months, we put some of these animals into a rich environment, which is a box with several teaspoons, and we changed the toys every two days," explained Tânia Viel, a teacher of the School of Arts, Sciences and Humanities at USP and project co-ordinator.
The test lasted four months, and later they were sent to the automation of a motorized activity, through sensors, and spatial memory, with a Barnes lawn test. The results show a transgenic mice stimulated by the toys with a 24.5% reduction in time to surrender to the labyrinth test compared to the animals that were not in the rich environment.
Mice braids were also explored. When studying brain samples, the researchers found that the transgenic animals were past the reasons why; shows a decrease of 69.2% in the overall density of gun plates, compared to those not motivated.
In addition to the reduction in senate plates, they have expanded protein that will help to cleanse their; this record. The SR-B1 receptor, which is pronounced in the microglia cell. The keeper causes these cells to be attached to the plates and help them to remove them. "The preserved animals, without the disease, helped to clean their appliances, even everyone who produced their protein. This was a significant reduction in Alzheimer's animals on protein and animals from the rich environment [que tiveram estímulos] Similar to animal control, "explained Viel.
The researcher says that the work is proof of assumptions before and that it is now in place; The organization works to expand the declaration in dogs and people. For this, it will be essential below to find a mark in the blood that identifies Alzheimer's disease relationship.
"In a rat, we analyze the brain and the blood to see if these bio-marketers are in the brain and in the blood. When the memory is lost, some of protests that increase the brain and others that reduce it. In dogs and in humans, we are only seeing blood, "he said. By detecting the symptoms in the blood, it is possible to perform mouse-like experiments with motorized and memorable experiments to reinforce or express changes in dogs and people after the reasons.
For Tânia Viel, because the person who causes the disease is not aware, the more it increases the mind in life, it is best to protect the brain. "It's changing your way. Many people say they did not have time to do other things, but if the person has the conditions and they can walk around their block, he's starting the Without doing physical activity and fun activity, dog walking, with a child, a language course, a dance. This helps to maintain the brain, "it's a # 39 ; praised.
The study was published in the Frontiers in Aging Nuclear Science magazine and was supported by the Foundation for Investigative Support for the State of Sao Paulo.
Tobar: Agência Brasil
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