Protein with intestinal bacteria to prevent obesity. How does it happen?



Diversity is associated with high levels of body light, but the basic evaluations are not yet clear.

However, a team of researchers have recently discovered how an anti-inflammatory protein affects weight, since there is a complex relationship between success, severe bacteria and obesity.

Recent research in Cell Host & Microbe says its anti-inflammatory protein NLRP12 is a & # 39; protect against obesity and insulin suffering in mice.

The survey was carried out by researchers from North Carolina University in Knockhill, as well as colleagues from other scientific research centers around the world.

The researchers also said that NLRP12 gene, which is connected to & # 39; anti-inflammatory protein of the same name, which appears unofficial in people with obesity.

NLRP12 also encourages a unique growth of intestinal bacteria (beneficial) problems, which additional protection impact on obesity and insulin resistance.

"Disease affects disease, not just consume and lack of exercise. This study shows that weak reduction helps bacteria to help them achieve healthy stress , "said the author, Jenny Ping.

Impact of gene activation inflammation

Scientists in recent research have been trying to show how NLRP12 gene affects a person's risk of obesity.

To do this, they tested with mice that were altered to present this gene.

Ting and the natural mice and mice team gave a diet that was full of fat for several months.

Although there was a mice in each body that followed the same diet, fat accumulation was faster and bitter; easier in the mice, as it began to show insulin signals, which are all in a position; indicates the development of obesity.

The mice that did not include gene NLRP12 also had a & # 39; Many burn in the two bones and in other areas of their bodies where it is fat.

However, researchers took an extra step to understand the connection between light and weight gain, and # 39; Moving some of the test mice into a different facility and preventing them from antibiotic drugs to prevent the spread of disease.

"We noticed that antibiotics that had been discharged by antibiotics were out of their mice in the old facility," Agneska Traxal explained. "This helps us to make sure bacteria are intense to help with obesity."

Fuel bacteria may have a major role

Explore Ting and her moth medicine team who lived in a free environment of bacteria and noted that they did not. get too much pressure.

They decided that this was because bacteria activity did not; affecting the systems of animals.

In this case, the NLRP12 mice does not have an emphasis on stress, suggest that some types of bacteria may be a key factor for depression.

The researchers also make another interesting note that there are mice that have been involved in healthy creatures where they were; live, and said that NLRP12 gene was not under pressure, either.

This shows that they have been open to productive mice from a management mice, which protects them from being infected. show more pressure.

Such results show the context in which checks have shown that obesity is associated with a variety of bacteria in the variety of; bone.

In addition, some vegetables are obstructive to obesity, and allow the rest of the recyclables to be reconstructed without a competition.

Risks of bacteria

In the recent research, researchers found that rats that NLRP12 exams did not offer a significant loss of bacteria diversity.

In this case, the fatty diet is as good as the help of lunch; Increased by NLRP12 deficiency to high levels of Erysipelotrichaceae.

The researchers also found that these bacteria are causing damage to their symptoms; cause high nutrition.

At the same time, the mice lost a number of beneficial lactobacteria (Lachnospiraceae), which help to combat the disease and its disease; Competitions with Erysipelotrichaceae bacteria to defeat the spread.

The researchers found that Lachnospiraceae had an adverse effect against insulin attack and mice obesity.

"When we introduced Lachnospiracea bacteria, it especially revealed the metabolic and ingenious changes we saw in NLRP12 for a test mice when they were getting high fat foods," said Trax .

Obesity may have better results on dealing with obesity.

"Lactobacterium (Lachnospiraceae) produces a short series of salted acids, a kind of metabolism-related molecular substance," said the science.

Both butyrate and propionate are also important anti-inflammatory properties.

When trying to test mummers and probiotics, the researchers found that this approach was parallel to the impact of NLRP12 loss.

Demonstrating therapeutic opportunities

These results are particularly encouraging that butyrate and propionate are easily accessible as improvements.

In addition, scientists have a good reason to believe that the concepts (in mice) are similar in humans, as there are additional surveys of cell samples fat collected from fattened people; BMI), more active is NLRP12 gene.

"In rats, we have shown that NLRP12 reduces the blast in the carcasses and in licensed devices, and although it is difficult to direct human effects, our partners has helped us to show low levels of NLRP12 attendance in overweight individuals, "said Jenny Ping. South Westerly


  • Translation: Zeinab Abbas.
  • Analysis: Suha Yazji.
  • Editing: Issa Hazeem.
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