Scientists will identify a specific eczema subcategory linked to food allergy



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Press release

Wednesday, 20 February, 2019

All contracted children acquire uncommon skin near productivity, receive funding from NIH

Atopic dermatitis, common skin conditions, is commonly known as cancerous eczem, which affects almost 20 per cent of children, with 30% also having food cheeses. Scientists have now discovered that there are structural and molecular differences in the highest strains of a drug that looks healthy near patients with atopic dermatitis and redirect patients food, but only children with atopic dermatitis. Exploiting these differences can help to & # 39; identifying children at the high level of risk for developing alanguage food, according to research published online today Transitory Science Science. The research received support from the National Institute of Art Gallery and Invasive Diseases (NIAID), part of the National Health Institutions.

"Children and families affected by food allergies must always protect against food that can adversely affect the life of cancer," said NIAID Director Anthony S. Fauci, MD "The eusemem of a risk factor for the purpose of producing food allergies, so early intervention to protect skin care may be a major place to prevent food hospitality . "

Children with atopic dermatitis develop dry, poor, skeletal skin panels caused by cancer burning. The symptoms of atopic dermatitis come from a small toxic discomfort that prevents the baby's sleep and can recycle disorders of broken, broken skin.

The study, led by Donald Y.M. Leung, M.D., Ph.D., of the National Jewish Health in Denver, examined the highest strings of the skin, called the corneum stratum, in areas with a chrome lion and in a normal skin. The survey recorded 62 children aged 4 to 17 years of age with atopic dermatitis and pipe conditioning, atopic dermatitis and no evidence of any food or any pharmacy. Inspectors would collect skin samples by copying; Insert and remove small, non-fertile failure rods to the same area of ​​the skin. With each movement, microscopy subgroup of the first series of skin woven was collected and preserved for analysis. This approach allowed researchers to co-ordinate the skin, protons and fat, as well as the microbial communities, their generation in skin cells and loss of water through the skin's lump.

Researchers found that the children's skin fragrance with atopic dermatitis and food alarms was not separated from the skin's love with atopic dermatitis only. However, they found major variations in the structure and molecular writing of the highest series of unusual, healthy skin between children with atopic dermatitis and a food alarm compared to children with atopic dermatitis only. Uncommon skin from children with atopic dermatitis and food recharges was more likely to lose water, there were plenty of bacteria Staphylococcus aureus, and gene representation was used as an inconvenient barrier. These numbers were also seen in skin with active atopic dermatitis drinks, which results in skin disorders; stretching beyond those that are apparent in children with atopic dermatitis and food guides, not just those with atopic dermatitis only.

"Our team was trying to understand how skin that looks healthy can be different in children who develop atopic dermatitis and food allergy compared to children with atopic dermatitis alone, "said Dr Leung. "Interestingly, we found these differences within the skin of the skin but in samples of skin trees without being able to look away. These ideas could help not only do you understand better atopic dermatitis, but we will also recognize the biggest children at risk of developing food artefacts before they bring a skin or non and, finally, strategies will be a healthy barrier so that fewer children can be affected. "

Artifacts suggest that atopic dermatitis is an early stage in the "atopic march", a continuing general improvement found in some children with atopic dermatitis. going on to food allergies and, sometimes, to respiratory allergies and cancer asthma. Many immunologists suggest that food allergens are able to reach protected cells easier by preventing unnecessary skin that is adversely affected by atopic dermatitis, and so on. removing biological processes that produce food cheeses.

NIAID supports and supports; supports NIH's research, across the United States, and around the world – to explore the causes of infection and infectious midwifery, and develop better ways of preventing, diagnosing and treating these diseases . Press releases, information leaflets and other NIAID related materials are available on the NIAID website.

About the National Health Institutions (NIH):
NIH is a country's medical research agency, comprising 27 Institutions and Centers and is part of the United States Health and Human Services Department. NIH is the leading federal body that guides and guides; supports basic medical, clinical and translation research, and examines the causes, cures and treatments for common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

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Mention

D Leung, et alPost-natal skin surfaces indicate atopic dermatitis with food allergy as a separate endotype. Transitory Science Science DOI: 10.1126 / scitranslmed.aav2685 2019.

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