An analysis shows how the cells of protection have attracted different targets



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For the first time, researchers have shown the exact different images of important migratory cells, known as the regulatory cells of T, and # 39; Using single cell genomics, in the remote non-lymphoid thrush of the mouse and the human, such as skin and collar. Researchers from the Wellcome Sanger Institute and their colleagues revealed that T's regulatory cells have specific crafts and other adaptations that allow them to move into and live in the right place in the body . In the future, this can allow us to understand how to trigger target cells to specific parts of the body, for example, remedies of self-contained diseases, for example.

Recited Immunity (5th February), the study found that the control cells of T-mice on multi-dimensional multi-dimensional states, both inside and between weeds. They also found patterns of gene activity in humans, and show more information than ever about how the immune system is managed.

T (Tregs) control cells are a special type of protection cells that control the protection system. They release the protection protection to keep it in a check and a & # 39; preventing his / her body to be & # 39; attacking its own insects. These cells are found in lymphoid mussel such as loops and dolphins, and also in other non-lymphoid weeds in the body. Although there are some recognized differences in how the regulatory cells of T work in different materials, there is an understanding of the "GPS system" that is in place; Remarks cells to specific devices in the body are limited.

In order to create a detailed T of cells, researchers searched 35,000 cells independently of lymph mouse, tissue, skin and colored trades, which compiled cells across the various materials. They used the ordering of single cell RNA to find out what the genes were put forward in each cell. The researchers found that there were different different parts of cells between different materials and revealed the changes that T's cellular control rings move between devices.

Further analysis revealed that even within one weave, was different from cells – with continuation of cell states and regulatory functions. They also find that, although the cell states row is very similar when moving to different remote files such as skin and collar, cells have a cell; including placekeepers & chemokine & # 39; Especially on the surface that is used as a shine to guide them to specific devices.

Tomas Gomes, the first author from Wellcome Sanger Institute, said: "This is the first time that a person has described the wide range of T cellular controls in remote devices. We can see that although These cells integrate the basic identity of regulatory cells, they are very different across different materials, with different roles, and even add different characters to Directed to a specific device. This helps us to understand the management of the security system to keep it in healthy balance. "

The researchers analyzed Tregs from muscle and non-tumor cells in specific materials and saw that they had the same genera. Comparing mouse data with Tregs from human skin, colons and blood devices, they found similar appliances and they were. specification of molecules in humans.

Professor Fiona Powrie, from the University of Oxford, said: "We now know that Tregs have special responsibilities in different materials, some of which are different from their impact. By showing the general and different molecular features that support Treg's different statistics, research provides a better understanding of how Tregs interacts with, work with their environment to encourage knitting health throughout the organization. "

Dr Sarah Teichmann, a similar author from the Wellcome Sanger Institute, said: "This is the most extensive study of the single-cell RNA control cells on the control cells of T in meat. – it does not help us to understand the security system in knitting, it also shows what controls and devices that contain each device. This can help researchers learn how to deal with tough T cells in the future, design them for specific places in the body and directly focus on them Need proper tools. "


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More information:
Immunity (2019). DOI: 10.1016 / j.immuni.2019.01.001

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An analysis shows how the cells of protection have attracted different targets (2019, 5 February)
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