Duke-NUS researchers show an author's investigation on the dengue



Resistant cells in the skin are amazed by researchers by clicking on " Creating a corporate relationship with the abolition of T-dead.

Inspectors at the Duke-NUS Medical School have shown for their first time corporate interaction between two types of protection cells that are very important in the fight against disease; dengue virus.

Dengue virus infection figures have grown dramatically over the last few years, with estimates that suggest 390 million annuities annually.

"We need a much better vaccine for dengue and for viral pathogenes linked to mosquito skin," said Dr. Ashley St. John, Professor of Investigative Program, Mandatory Disease Signage (EID) DukeNUS & # 39; and author correspondent to the South-

Dr St. John and co-author of Dr Chinmay Mantri, Investigator in & # 39; EID Program, which explores its location; made by a type of colon, known as a tree cell, which protects its & # 39; skin to protect against infections. Mast cells have been widely recognized for recruiting other types of protective cells through a & # 39; Distributing chemicals that are a special attraction. Much is understood about how creeping cells affect the presence of bacteria and parasites, but recent diagnosis of their posts with viruses. The researchers investigated the growth of dengue virus in an animal pattern without any tree and compared the responses to animals with normal numbers of cranes to find out what reagents that depend on a mast.

They found that several types of protective cells screwed to their disease site. One of these is called T gamma delta (γδ) cells. It was not only that T γδ cells were tired to the site of disease, they also interacted corporally with the cranes, something that was not previously seen in viral infections. T γδ cells connect to a receptor who has a & # 39; appears on a spray called the endothelial protein C receptor. The synapse immune & # 39; This is progressed to the cells of T operating, expanding, and & # 39; Gambling a gamma, which started the place in cells that were converted by dengue.

The authors of the re-plan use the search results to work on the development of a better vaccine for viruses, such as dengue, which are spread by mosques.


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