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A Slovenian researcher in London got Jernej Ule money for European brain research




Brain. Photo: Laboratory Ule

On the offer ERC Advanced Grant 2018 More than 2,050 applications were submitted to researchers, and 11% were selected for funding, which demonstrates the success of the Slovenian researcher, the director at the media conference said. Gregor Anderluh Chemical Institute.


Jernej Ule Photograph: Jernej Ule

They keep up with money ERC– he has set up a new research organization at the Institute of Chemistry in which, according to Anderluh, around six to eight researchers. Department of Molecular Biology and nanobiology. Some of the project will also be implemented in the school University College t London (UCL).

Searching the brains search the brain
A five-year project entitled title RNP Dynamics it will explore how the management of molecules is RNA it contributes to the development and functioning of the brain and how the errors in this rule are governed gradually diseases like amyotrophic lateral sclerosis (ALS) a Slovenian researcher professor moilecular brain experience advancing UCLUle.

Over and above this, the project is also looking at how the errors in the links are up to date proteins inner RNK (ribonucleic acid) damaging the activity nuts and thus causing the disease ALS. This will form the basis for developing new strategies for disease management using RNA recommendations.

According to Anderlech, this is a basic research project where they do not develop medicines for cures ALSbut they will have a better understanding of the reasons for this. "I am sure that the project outcomes will underpin the development of medicines and strategies to treat this disease in the future" Anderluh said.

Research will be based on methods that monitor intact cellular networks of molecule links that provide large amounts of data. These data will then form the basis of computer analyzes that need to detect changes in molecular communication, which are important for molecular atomic dynamics and therefore develop early brain development.

Researchers at the Institute of Chemistry collaborate particularly in the area of ​​structural biometrics and structural chemistry, thereby helping to understand molecular structure and interactions and in a modeling field. T a computer of processes that happen in molecules within our body.

Jernej Well, to the ERC fund

"Sympathy affects the heart"

There are other projects in Chemistry Institution
The eighth project is Uletov's project ERC-This project was conducted by a Slovenian research group and on the fifth project in the scheme for established researchers. This is the second Slovenia ERC-The Chemical Institute's original project was titled, with the title, title MaCChines, last year Roman Romans.

Anderluh also delivered the project, at the event Màiri Curie Skodlowska Activities – tIndividuals Trusts Indian and Italian researchers and research equipment, which will be submitted to their laboratory soon.

As he said, this year it is also planned to update scientific research equipment in the Institute's framework Higher. T center for NMR, t Spectroscopy High Definition and buying a new one brain a unique microscope area. t. It enables exploration of biological macromolecules structures and buildings with atomic resolution and so on "greatly enhanced the research capacity in the area of ​​life sciences"Anderluh said,

At the microscope presentation, they will organize a conference at the Chemistry Institute, where they will host the Nobel Prize winner. Joachim Franck. This is in 2017 with researchers Jacques Dubochet inner Richard Henderson he has been awarded the Nobel Prize for Chemistry for Development cryoelectronics macroscop.


The Slovenian publication in Nature: how the cell guides the film of life

How cells in the brain control breeding
A Slovenian researcher graduated Jernej Ule from the Biotechnology Faculty of Ljubljana and then received a PhD at the University of Rockefeller in New York in 2004. In 2006, he established a research team in England, first at Cambridge, and t now professor moilecular brain experience advancing UCL in London, and her steering group at the Francis Crick Institute.

It addresses the issue of how links between proteins and molecules are formed RNA and how this plays an important role in the interpretation of genes. During his practice, he developed a new approach for this purpose CLIP, then its group developed further versions of the script, such as iCLIP inner surrounded. Using these methods, it examines how the cells in the brain control the breeding.


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