They identify a topical target to face metastatic and invertebrate cans; protests


After 12/15/2018 15:06:39CET


Researchers from the Bellvitge Biological Research Institute (Idibell) and the Oncology Institute of Catalonia (ICO) have identified a new risk to attack in more aggressive, metastatic prognosis cans that have been resistant to hormonal treatment.

The study, published in the journal & Nature Communications & # 39; and also including researchers from the University of Columbia and the University of Bern (Switzerland), and Opening the door to treat a new variety to deal with this cancer type, Wednesday Idibell and ICO.

Researchers have confirmed that these tumors create greater levels of NSD2 protein as tumor progress is increasing; go ahead and get rid of medication, and they have confirmed that these tumors are true, to continue to get them; grow and spread, depend on its & # 39; this protein. , and thus represents a topical target that is & # 39; emerging.

They have used a series of sets of transgenic mice that are most common in brutal cancer patients, Getting involved in the epithelial cells of a stroke of creatures, as is the case of most patients.

Based on these models, once the mice has developed cancer, cellular and middle-class cell cells have been remote and there are patterns of gene representation.


By using biological tools, researchers have identified candidate genes to represent vulnerability in these aggressive tunnels, and factors that, in a different way, are present in malignation and metastisis.

NSD2 is a protein with an activity that involves chemical changes to prototypes that provide structural support for DNA series, known as histones.

The changes in these historical are given by the NSD2 activity causing rest in the comparative stages of the DNA lines, express a pronounced phrase of a gene with a tumoric ability.

One of the key ideas of the researchers who indicate this investigation is that the implementation of these genera as a result of the NSD2 activity is dependent on Strive to chemotherapeutic healing that is usually given to cancer patients. Prostate

Researchers are working with molecules that can prevent NSD2 work and, thus, reduce ill-health prospect in mice, and that is; means that there is an increase in its experimental mode.

They believe that this diffusion could be a & # 39; Continue to reinstate tumors prostain that appear against normal antiandrogenic remedies.

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