"This is a powerful review, and a step forward for our understanding of Alzheimer's," said the neurologist Dr. Richard Isaacson, who leads to Medicine Weell Cornell's Prevention Alzheimer's Clinic.
"Getting these new generaces allows clients to give a single-day target for those genera with remedial interventions," said Isaacson, who was not involved in the study . "It also gives us an understanding of Alzheimer's causes."
Herald Snyder, Alzheimer's senior director of medical and scientific work, was not involved in the investigation. new.
"That said, they provide a useful insight into the physical processes that may cause or disrupt the Alzheimer's and other dementia's changes," said Snyder.
By increasing the numbers to 94,000, the new survey added 30% more data to the analysis, and allows researchers to add 20 genera previously identified and four.
How are the new genera – IQCK, ACE, ADAMTS1 and WWOX – together with a previously discovered gene called ADAM10, which affects Alzheimer's development. But once their specific actions have been recognized and monitored, researchers say they will be able to develop drug potential targets.
"Alzheimer's disease is a complicated disease. It is not like Huntington or Parkinson, where one gene has changed and you will get the disease," said author Margaret Pericak-Vance, director of Hussman Institute.
"With Alzheimer's, there are several genes working together," said Pericak-Vance. "We tried to find the rare changes that could contribute to Alzheimer's. And we could not do that before. We just had size of sample to do. "
"We saw an amalyoid early, but it was not confirmed in [genome-wide association study], "Tanzi said." So I think it's an interesting thing; that he is returning to amyloid as the lead player.
"I should also say that we also see that there is a defensive in another major path beyond the amyloid," said Tanzi. "In this study, we see a protective gene that is affecting neuroinflammation."
Content in an important neuroinflammation, Tanzi says, "as at the end of the day, plates and tangles can be on the platform, but it is inconsistent that enough neurons are killed to get to dementia. "
Now giving more than a dozen target target on how to protect its vulnerability. Alzheimer's relationship, Tanzi said, "a new drug should be" seriously damaged. "
The increase in the sample size allowed the researchers to find "gene locations" that could affect Alzheimer's development. "And some of these genealogies have the potential to do more than one activity," said Brian Kunkle, the author, scientist related to the Hussman Institute.
"Perhaps they are increasing risk through different disease paths," said Kunkle. "Risk assessment and treatment for each person will be in charge of the type of changes that a person has in each of the 25 genera or other bio-markets."
Isaacson said that the ongoing work could continue to "be the best of herbal medicine at the best."
"A person can bring many different ways to Alzheimer's," said Isaacson. "If we can find out what way a person is going on by identifying a particular gene, we can have a specific interconnected target that can work favorably for that particular person. "
As to when this may happen, Kunkle is cautiously optimistic.
"It's hard to say if he will help someone who has Alzheimer's at the moment," he said. "We hope contracts will be developed for the family that may have those that are putting them at risk."