An international study, with the participation of Spanish researchers, has been identified dozens of genes that contribute to the deficiency of an obstruction deficit (ADHD) and have developed the first genetic map of this geography. In the work, published by the "Nature Genetics" magazine, more than 80 authors from 60 research centers participated, including researchers from the University of Barcelona (UB), Hebron's Hospital Vall, Mutua Terrassa Hospital and the Institute of Global Health Barcelona (ISGlobal).
The research has examined almost ten million genome jobs in more than 50,000 people from different countries in Europe, the United States, Canada and China. After this analysis, this is the first genomic global study of ADHD, researchers have identified two distinct DNA specifications related to liability for this situation, one of the problems The most common mental in childhood and youth is around 5% of children and 2.5% of adults.
It is marked by ADHD attention deficit, mental illness and stimulating behavior, and limit the personal and social skills of the affected people. With the first thing that is not knowledgeable, everything is a n; indicates that ADHD as a result of a variety of environmental factors (toxicological, psychosocial, etc.) is a political hereditary base (which has been described about 75% of the disorder).
The work, led by the universities of Harvard and New York (SA), and Aarhus (Denmark), has focused on investigating the place where the general genetic changes are generally in the by-order. The study has shown that the genetic changes are "21% in ADHD's full genetics", according to Bru Cormand, the head of the Neurogenetics Research Group at the UB Biology School.
"In addition," he said, "most of the known genetic changes are found in categories of genes that are very high throughout development, which indicate their relevance active. " In particular, the research has identified two genomic sections, and ten of them respond to a specific gene, and including susceptibility to ADHD and have found that many of the genetic changes associated with this disorder influence the regulatory elements of gene gene in the brain .
Among the cookies that have been identified, the FOXP2 gene stands out – one of the largest language development studies in people – Bring a protein with a prominent place in creating neuronal synapses and learning. FOXP2 has already been identified as an advocate generator for ADHD in the 2012 study in which a number of Spanish writers have been re-launched in this new work and is now one of the next genera are mentioned in the scientific literature that appears in this new map of ADHD.
One of the genera identified – DUSP6- is involved in the control of dopaminergic neurotransmission, which is the target process for the most common medicinal remedies of ADHD. The third generation, SEMA6D, which is pronounced in the brain through creative development, can create an important part in creating neuronal branches. The international study has also reviewed the shared genetic basis between ADHD and more than 200 features, both psychiatric and non-psychiacric.
According to Cormand, "the findings show genetic arrangements between ADHD and severe depression, anorexia, education levels, obesity, breeding success, smoking or insomnia." According to Cormand, "this study confirms, in opposition to some of the voices of confidentiality, the idea that ADHD is a disorder with a strong biological base, in which many generations say."
The Catalan researcher has emphasized "the importance of promoting major audiences that can only be done through international major partnerships to examine the genetic basis of complex brain diseases . "