Insomnia, capable of causal causes in corona arctic disease



An international research team led by researchers from the Massachusetts General Hospital (MGH) and the School of Medicine at the University of Exeter in the United Kingdom has identified 57 genetic aspects related to identical symptoms. His report, which also shows a causal link between anomaly and coronary artery disease, is published in the online journal of & # 39; Nature Genetics &

"Our conclusions have to verify the place of genetics in the membrane and extend to the four genetic loci previously found for this fragrance," said the the author of his & # 39; paper, Jacqueline M. Lane, from the Center for Genomic Medicine and Department of Anesthesia, Critical Care and MGH Medicine Pain. "All of those acknowledged areas help us to understand why some people suffer from suffering because of their impact on paths and systems and expressing them new attractive targets, "he says.

Insomnia affects about 10 to 20 percent of the population, and surveys about twin and family members have suggested that about a third are some of the dangers; has been getting insomnia. Although the evidence suggests that insomnia can increase the risk of anxiety, the problem of using alcohol, major depression and cardiometabolic disease, we do not know much about the media involved.

The 2017 study identified the Genetics of Nature & # 39; led by Lane and Richa Saxena, MGH Genomics and Anesthesia Center, three genealogical sites related to insomnia marks reported with more than 112,500 UK Biobank partners. For the current survey, the team provided data on data from over 450,000 partners from the UK Biobank, and 29 per cent reported that there were incidental factors.

The analysis linked to gene sites 57 with the tranquility of self-esteem, connections that did not affect known risk factors, such as way of life, caffeine, depression or recent stress. The identified genomic areas include a gene that is involved in ubiquitin-mediated proteolysis – a process where proteines are listed to be destroyed – and expressed in different areas of the brain, invasion muscles and the adrenal gland.

Although some of these generaes include links between symptoms of paths, castered legs, and coronary artery disease, the identified areas did not; including a neurotransmission generator who is familiar with sleeping control.

To confirm whether the UK Biobank results are compared to other numbers, the data authors have changed the HUNT analysis, an epidemiological study in Norwegian, and the Biobank Partners in Boston (United States ). A comparison of 15,000 participants in the HUNT survey reported a patient's indication of more than 47,600 control and 2,200 Partners Biobank partnerships with a clinical diagnosis of problem with 14,240 control of the proof of UK Biobank results.

New attractive targets that may be there

Data recommended by a sub-group of nearly 85,000 partners in the UK Biobank that used accelerometers for moving up to seven days for genera-related genera related to insomnia to reduce sleep efficiency (measure of quality of sleep). sleep) and sleep, and high day-to-day changes in sleep. The associated genetic causes associated with insomnia and irresponsible casualties support the work done by the MGH team before and they are; suggest that this may be a cause to cause unexpected cascades in some patients.

There is an analysis method called Mendelian randomization, which may occur if one of the two characters that appear in individuals causes the other cause, and shows that the increase in insomnia symptoms is dependent on coronary artery disease – its risk doubling, symptoms of depression and nutrient reduction. "Insomnia has a huge impact on millions of people around the globe. We know that there is a long time between insomnia and infections. Now, our conclusions come out to Depression and heart disease are a result of continuous disorders, "said co-author Samuel Jones of the University of Exeter.

The MGH Lane researcher says: "All of these recognized areas are all of these new attractive targets for insomnia, and 16 of these areas have drug sensitive targets. , the new causal relationships show how useful the insomnia medications are and what can be cure for regional arthritis and dementia disease. "

Co-author Michael Weedon of Exeter University says: "There are problems with current remedies for insomnia, including access problems, problems and consequences. We hope to have a greater understanding Detailed the processes involved in insomnia reduce the route for better and more personal treatments, which may reduce the number of people suffering from insomnia and improve long-term health. "


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