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A new non-antibiotic strategy for treatment of bacterial meningitis

** New non-antibiotic strategy for treatment of bacterial meningitis

Observing here is the presence of white blood cells (neutrophils) in vertebral column as a result of bacterial meningitis. The nuclear matter is colored blue and proteins in neutrophils are red. The large collections form represented by the blue fields of DNA (DNA) and red (protein) presenting the DNA-profile networks known as neutrophil (NETs) derivatives. NETs are released as a protection against bacteria that are attacked by bacterial meningitis. Credit: Tirthankar Mohanty

With increased threats to antibiotics, there is an increasing need for new processing strategies against bacterial infections that affect life. Researchers at the Lund University in Sweden and Copenhagen University may have thought of having similar treatment for bacterial meningitis, a serious illness that could lead to sepsis. The review is published Nature Communications.

The defense system has a number of important defenders against injury from the central nervous system. The researchers have reported what happens when white blood cells called neutrophils are broken into bacterial meningitis. The neutrophils use in the disease environment to catch and neutralize the bacteria. It's a hard battle, and the neutrophils usually die, but if the bacteria find it difficult, the neutrophils go to other devices.

"It is in true pressure, they are turning themselves in an emergency to find the bacteria that they haven't been caught. By using this technique, they capture a number of emotions. These are often used in several structures in a similar structure to nets, or neutrophil locks (NETs), which work well in many parts of the body, where the NETs in which the bacteria are caught can be found. behavior in the blood and then neutralized in the air or spleen, for example, the NETs are caught in a cerebrospinal area, and the cleaning station is not very effective, "explained Adam Linder, professor of nutrition. at the University of Lund and an expert on Acute Illnesses at Skåne University Hospital.

By using a progressive microscope, the researchers studied that cerebrospinal fluids were patients with cloudy meningitis and glues, which were NETs. However, among patients with viral meningitis, the cerebrospinal fluid was free from NETs. When trapped bacteria are caught in cerebrospinal fluids, it can affect the immune system's work by removing bacteria and also removing antibiotics from getting to the bacteria t And Adam Linder says.

Could the nets be cut to allow the bacteria to be exposed to the immune system, as well as antibiotics, which make it easier to stop the disease? Because NETs are predominantly DNA, the researchers explored the corresponding use of drugs that cut up DNA, as DNase fled.

“We gave DNase to rats that have pneumococcus disease, which causes bacterial meningitis, and that appears to have been removed by the NETn and that the bacteria went away. to stop the single-handed bacteria and we found a huge reduction in the number of non-antibiotics helped to bring in antibiotics, "said Tirthankar Mohanty, one of the researchers involved in the survey.

Before antibiotics, the rate of mortality for bacterial meningitis was around 80 per cent. With the advent of antibiotics, the death rate fell rapidly to around 30 per cent.

In the 1950s Professor Tillett at the University of Rockefeller discovered lumps in the cerebrospinal pool of patients with bacterial meningitis. Professor Tillett found that these tips could be dispersed using DNase. This was effective in conjunction with antibiotics, and reduced the rate of death due to meningitis from around 30 per cent to around 20 per cent. However, this therapy had different effects, due to the removal of the DNase and so it could inspire air effects.

“At that time, everyone was so happy about antibiotics – they reduced mortality for the diseases, and it was thought we won the war against bacteria. I think we need to go back and take part of the research. We can, perhaps, learn from some of the things that were then flushed down the drain, "said Adam Linder.

"The development of conflict in bacteria is accelerating, and we need alternatives to antibiotics. The type of medicine we use in these investigations is biological biological results which come from humans and is from the human diet. already licensed for use in humans. Rowan meningitis is a major challenge in many parts of the world. The Indies, for example, are a major cause of death among children, so children would need to be treated like cancer. great benefits there from the use of such a management strategy. "said Tirthankar Mohanty.

The researchers want to establish a major international clinical study and use DNase in the treatment of patients with bacterial meningitis.

A – Z infectious diseases: identifying meningitis

More information:
Tirthankar Mohanty et al. Archaeological ribbons of neutrophil in the central nervous system prevent bacterial clearance at pneumococcal meningitis, t Nature Communications (2019). DOI: 10.1038 / s41467-019-09040-0

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