As part of compiling the largest map of Alzheimer's human brain, researchers have found more evidence that some of our self defense can be protected itself against the effects of of the disease.
The team saw that the cerebellum – that section of the brain that is responsible for movement and balance – is a major impact but as a result of Alzheimer's disease, which may indicate the brain to trying to set up protection.
This is important because there is a suspicion that the disease, along with areas such as motorcycle and the cortex is not aware, and Find out how the disease is spent as other brain divisions. But no one definitely sure why.
In this study, the team saw that the camcorder is going through additional changes following Alzheimer's strikes that are not seen in the # 39; motor and sensitive chromas.
In other words, there appears to be something special that occurs in the # 39; hedgehogs, and scientists say that this could help to improve cures that do; identify this behavior.
"The circle, which he thought before [to] has no impact, which demonstrates a significant molecular response, "said researcher Richard Unwin, from Manchester University in the UK.
"Many of the changes here are not seen in other areas and this may mean that this section protects itself from infections. We do not know exactly so we can do more research. "
In particular, the cerebellum is not unique when Alzheimer's has changed, but it is changing in a way that differs from other parts of the brain – especially the amyloid and taught construction ; mark the disease in the & # 39; Most of the brain.
For now it's just the opinion, but the researchers believe that some of the fastest meals could be at & # 39; A small brain of cerehenum is not the rest of the brain.
For the study, the sciences looked at nine brakes from people who had died with Alzheimer's and nine healthy steps from people who died from other causes, including heart disease, lung disease and cancer.
They were capable of mapping 5,825 types of protein over six different brain divisions, giving them 24,024 data points altogether – and financial information for researchers wishing to monitor Alzheimer's progress. The data is now publicly available online.
"This database provides great opportunities for dementia researchers around the world to progress and to continue new areas of biology and its; develop new remedies, "said Unwin.
"It may also help to verify observations in animal models or cell diseases in humans. It is very interesting to be able to make this data public so that science to use and use this essential information. "
The search was closely related to the & # 39; arthritis, a gyrus, and a hippocampus, which is expected to start Alzheimer's. We already know that these brain divisions are likely to be attacking Alzheimer's.
It was in the other areas where it was found to be a major surprise: the motorcycle and the cortex were fully realized, as was expected, but the circular revealed a different pattern of Prostative changes that may be defensible.
Unfortunately, Alzheimer's still has a problem, despite a lot of recent improvement in our understanding. In the last year; The researchers have identified a type of protection to Alzheimer's found in some people, as well as the potential to connect to gum disease.
This brings us closer to Alzheimer's, as the 44 new protein changes have been identified by this latest study. The team was also able to reflect relatively early and relatively late changes in protein words in spoiled brains – again, a useful knowledge of the operation of remedies in the future.
"We believe that the changes we see in the areas that are later influenced by the presence of early illness changes that are present before cell deaths, "said Unwin. "These represent good new targets for drug developers, because we know that it is important to try to early intervention."
The research was published Biotechnology of CommunicationsSouth Westerly